Gut Health Protocol
Dr. Galland is internationally recognized as a pioneer in gut microbiome research. After more than four decades studying the connection between gut health and systemic disease, he has identified specific, clinically-tested probiotics that can fundamentally restore microbiome balance and support healing.
Tundrex™ — The Alexander Organism Probiotic
Easy to carry · No refrigeration needed
Bacillus Subtilis: The "Alexander Organism"
Bacillus subtilis B-7092 · Siberian Tundra OriginOriginated in pristine Siberian soil and backed by decades of research, Tundrex contains a uniquely potent strain of Bacillus subtilis — the microorganism Dr. Galland calls the "Alexander organism" of the gut microbiome. Just as Alexander the Great organized vast, chaotic territories, Bacillus subtilis orchestrates and restores order to a disrupted microbiome.
- Microbiome restoration after disruption
- Secretes alpha-interferon (antiviral)
- Immune system reinforcement
- Digestive health normalization
- High survivability through GI tract
- Endosporal form — no refrigeration
- Soil-derived, organic sourcing
- 10 years of Dr. Galland clinical use
"Bacillus Subtilis is the best Alexander organism I have yet worked with, especially for people whose gut microbiome has been severely disrupted by one of the major pathogens. Once the pathogen has been treated, Bacillus Subtilis can take command of the disorganized, dysfunctional remnants of the microbiome and help to restore balance and harmony."
— Dr. Leo Galland, MD · New York, NY · Consultant to Tundrex📋 Dr. Galland's Dosing Guidance
Standard dose: 1–2 capsules, 5 times daily (every ~2 hours), with or without food. Each blister pack of 10 lasts 1–2 days. Typical course: 10–15 days for viral eradication phase. Higher dose (2 caps × 5x) if GI symptoms present; lower dose if no GI symptoms.
Tundrex Protocol Bundles
Tundrex offers targeted protocol bundles for specific health goals. Dr. Galland recommends the following:
Complete Microbiome Restoration Sequence
After the Tundrex viral eradication phase, Dr. Galland recommends these 6 components to establish a durable, healthy microbiome:
6-Component Microbiome Restoration
To be used after completing Tundrex viral eradication phase
| Supplement | Dosage | Purpose | Category |
|---|---|---|---|
Lactobacillus plantarumProbio7-AB21 (recommended) |
1 cap, twice daily |
Enhances anti-viral immunity; aids recovery; found in fermented foods like sauerkraut |
Probiotic |
Vitamin DWith fat for absorption |
2,000–6,000 IU/day |
Increases ACE2 levels; immune modulation; supports microbiome health |
ACE2 |
ResveratrolMaintenance dose after viral phase |
~1,200 mg/day |
ACE2 enhancement; T-lymphocyte stimulation; anti-viral properties |
ACE2 |
PrebioticsArabinogalactan or GOS |
2,000–5,000 mg/day |
Feeds beneficial probiotic bacteria; supports butyrate production |
Prebiotic |
Zinc |
30 mg/day |
Critical for T-cell function; accumulates in T-cells; anti-viral effects |
Immune |
Reishi MushroomsGanoderma lucidum — Host Defense or powder |
2 caps twice daily |
Balances T-cell response; controls inflammation; immune orchestration |
Immune |
Long Covid Recovery Protocol
Based on Dr. Galland's comprehensive white paper Long Covid: Prevention and Treatment (© 2024–2025), this protocol addresses the root causes of Long Covid — ACE2 deficiency and mitochondrial dysfunction — through a systematic, evidence-based approach.
ACE2 Enhancement Supplements
Foundation of Long Covid recovery — restoring the vital enzyme damaged by SARS-CoV-2
| Supplement | Dosage | Purpose | Category |
|---|---|---|---|
Vitamin DTake with fat for absorption |
2,000–6,000 IU/day |
Increases ACE2 levels in cells; broad immune modulation |
ACE2 |
Omega-3 Fatty Acids (EPA + DHA)Main side effects: diarrhea, heartburn |
1,200–2,400 mg EPA+DHA/day |
Stimulates ACE2 via apelin hormones; anti-inflammatory; neuroprotective; prevents abnormal clotting |
ACE2 |
CurcuminBioflavonoid from turmeric |
500–1,000 mg/day |
Increases ACE2 activity; broad anti-inflammatory; brain recovery support; potential direct anti-viral |
ACE2 |
ResveratrolFound in red wine; take with food |
200–1,200 mg/day |
Directly enhances ACE2 activity; kills SARS-CoV-2 and MERS; T-lymphocyte enhancement; brain recovery |
ACE2 |
Alpha Lipoic Acid (ALA)Antioxidant; 600mg/day helps nerve damage |
300 mg twice daily |
Prevents ACE2 destruction from inflammation; protects mitochondria; repairs nerve tissue |
ACE2 |
NAC (N-Acetylcysteine)Standard treatment for Tylenol overdose |
600–1,200 mg, 2–3× daily |
Protects ACE2 from inflammation; improves lung function; strengthens immune function; liver protection |
ACE2 |
Rosmarinic AcidFound in rosemary, basil, sage, thyme, oregano |
150 mg/day |
Enhances ACE2 activity; available from food or supplements |
ACE2 |
Mitochondrial Rescue — Mito Support Protocol
Restoring cellular energy production — validated in University of Pennsylvania research
| Supplement | Dosage | Purpose | Category |
|---|---|---|---|
Coenzyme Q10 (CoQ10)Ubiquinol form preferred at lower dose |
100–200 mg, 2–3× daily |
Core mitochondrial support; repairs "leaky gut"; improves blood vessel integrity; shown to help post-COVID fatigue |
Mitochondria |
Vitamin B1 / ThiamineLipothiamine (fat-soluble form) |
100 mg, 1–2× daily |
Mitochondrial function; stimulates conversion of pyruvate; POTS may respond to B1 |
Mitochondria |
Vitamin B2 / Riboflavin |
100 mg, 1–4× daily |
Mitochondrial support; 400mg/day shown to prevent migraines (linked to mitochondrial dysfunction) |
Mitochondria |
Vitamin B3 / NADHTake on empty stomach or sublingually |
20 mg twice daily |
Covid depletes B3; NADH form improves energy and mitochondrial function in CFS; safest form for self-treatment |
Mitochondria |
L-Carnitine |
500 mg, 1–2× daily |
Transports fatty acids into mitochondria; reduces lactic acid; critical for fat metabolism |
Mitochondria |
L-Arginine |
800 mg/day |
Improves blood flow; mitochondrial support component |
Mitochondria |
CreatineMonohydrate form; shown in clinical trial |
4,000–8,000 mg/day |
Significant improvement in concentration, breathlessness, headache, malaise in Long Covid clinical trial |
Brain/Energy |
Urolithin AAvailable as Mitopure online |
500 mg, 3× daily |
Tested in clinical trial; supports mitochondrial biogenesis |
Mitochondria |
Viral Eradication Protocol
First step: 2–4 weeks of herbal antivirals, then soil-based probiotics
| Supplement | Dosage | Purpose | Category |
|---|---|---|---|
Resveratrol (high-dose antiviral)Double-blind placebo-controlled trial |
1,000 mg, 4× daily × 7–14 days |
Shown to speed recovery from acute Covid-19; kills SARS-CoV-2; reduces hospitalization risk |
|
QuercetinAbsorption enhanced by lecithin |
300–600 mg, 3× daily |
Blocks viral spike protein from binding ACE2; anti-thrombotic; natural antihistamine; reduced SARS-CoV-2 infection in clinical trial |
|
Vedicinals-9Complex herbal antiviral — vedicinalsusa.com |
½ bottle after breakfast + ½ after dinner × 14–28 days |
Contains Quercetin, Curcumin, Baicalin, Luteolin, EGCG, Rutin, Hesperidin + piperine. Clinical trial showed increased viral clearance speed |
|
Tundrex (Bacillus subtilis B-7092)tundrex.co — Soil-derived probiotic |
1–2 caps, 5× daily × 10–15 days |
Viral eradication from gut; secretes alpha-interferon; shown to improve energy in Long Covid placebo-controlled trial |
Circulation & Anti-Thrombosis Support
For those with breathlessness, circulation issues, or symptoms beyond 3 months
| Supplement | Dosage | Purpose | Category |
|---|---|---|---|
Ginkgo BilobaTebonin (New Zealand) is most studied |
120 mg, twice daily |
Anti-thrombotic via platelet inhibition; synergistic with aspirin; memory enhancement |
Circulation |
Quercetin (anti-thrombotic dose)Taken with lecithin to enhance absorption |
1,000–2,000 mg/day with food |
Prevents neutrophil-initiated clotting; also mast cell inhibitor; anti-histamine |
Circulation |
Nattokinase |
100 mg (2,000 IU) twice daily, empty stomach |
Antithrombotic enzyme; heals blood vessel lining |
Circulation |
PycnogenolFrench maritime pine bark extract |
50 mg, 3× daily with food |
Endothelial healing; anti-inflammatory; anti-allergic; reduces mast cell activation. Dr. Galland: "under-utilized" |
Circulation |
VinpocetinExtract of periwinkle |
20–30 mg, twice daily |
Improves brain circulation; addresses COVID brain fog; improves lung circulation. Dr. Galland: "under-utilized" |
Brain |
Sleep Support
Sleep is critical — Covid clogs brain glymphatics that cleanse toxins during sleep
| Supplement | Dosage | Purpose | Category |
|---|---|---|---|
MelatoninStart at 1 mg; increase as tolerated |
3–10 mg at bedtime |
Sleep induction; also reduces inflammation and protects mitochondria; may reduce heartburn |
Sleep |
Magnesium GlycinateAvoid with kidney disease |
100–400 mg at bedtime |
Sleep quality; calms nervous system; improves energy; relieves palpitations; glycine enhances sleep |
Sleep |
L-TheanineFound in green tea; short-acting (~4 hrs) |
600–800 mg at once |
Sleep induction; anxiety relief; often combined with GABA for sleep maintenance |
Sleep |
Saffron ExtractDr. Galland uses Optimized Saffron (Life Extension) |
2 pills ~9 PM |
Controlled studies show improvement in sleep quality, anxiety, and depression |
Sleep |
Immune Support Protocol
Dr. Galland's immune support recommendations draw from his extensive research into T-lymphocyte function, gut-immune axis, and evidence-based natural compounds. These are for daily immune maintenance, not acute treatment.
Reishi Mushrooms
Stimulates balanced T-cell response and controls inflammation. Available as Host Defense capsules or tasteless organic powder (Health Ranger).
2 caps twice daily or 1 tsp powder/dayZinc
Critical mineral for T-cell function. Accumulates within T-cells and is released for anti-viral effects. Main side effect: nausea. Do not exceed without medical supervision.
30 mg/dayBlack Raspberry Concentrate
Shown to enhance T-lymphocyte activity by increasing gut bacteria synthesis of butyrate. Available from Berrihealth.com.
1 tablespoon dailyButyrate (Post-biotic)
Produced by beneficial gut bacteria; circulates throughout body and enters brain. Supports T-lymphocyte function and reduces inflammation.
~1,000 mg/day with mealsFermented Foods Daily
Yogurt, sauerkraut, and kimchi eaten daily enhance T-lymphocyte activity — the key cells that control viral immunity. Note: avoid if histamine-sensitive.
Daily with mealsVitamin D + Omega-3
The foundational immune duo. Vitamin D modulates immune response; Omega-3s (EPA+DHA) are broadly anti-inflammatory and neuroprotective.
D: 2,000+ IU · O3: 1,200+ mgPrebiotics (GOS or Arabinogalactan)
Feed beneficial bacteria that produce butyrate and support immune function. Take on empty stomach for best results.
2,000–5,000 mg/day, empty stomachQuercetin
Natural anti-histamine, mast cell stabilizer, and anti-viral. Clinical trial showed 92% reduction in SARS-CoV-2 infection risk among healthcare workers (with Vit C + bromelain).
250–500 mg twice dailyGeneral Wellness & Foundational Health
Dr. Galland's foundational philosophy: address the underlying causes of illness, not just symptoms. These diet and lifestyle principles, drawn from decades of clinical practice and research, form the bedrock of long-term health.
Diet Principles
Plant-Based Whole Foods
A 40% increase in vegetable consumption produces a 70% decrease in severe Covid illness (Johns Hopkins study). Eat fish, eggs, dairy, and a little meat — just a lot more vegetables.
Anti-Inflammatory Foods
Foods rich in polyphenols and antioxidants support ACE2 activity and gut microbiome health. Dr. Galland's Fat Resistance Diet outlines this in detail.
Fermented Foods
Daily yogurt, sauerkraut, or kimchi enhances T-cell activity and gut microbiome diversity. Note: avoid if histamine-sensitive (MCAS).
Intermittent Fasting
12+ hour eating window helps balance the hormonal system in which ACE2 is a critical component. If fasting worsens fatigue or headache, avoid — may indicate mitochondrial dysfunction.
Herbs & Spices
Rosemary, lemon balm, basil, sage, thyme, oregano, spearmint (rosmarinic acid) and turmeric (curcumin) enhance ACE2 activity. Use abundantly in cooking.
Hydration & Salt
Drink enough water to alleviate thirst. Unless you have high blood pressure, don't avoid salt. Critical for those with fatigue, dizziness, or orthostatic intolerance.
Lifestyle Foundations
Sleep
Sleep more than you think you need, on a regular schedule. During sleep, the brain's glymphatic system cleanses toxins. Covid clogs this system — consistent sleep is restorative medicine.
Exercise — Cautiously
Exercise is essential, but for some Long Covid patients even small amounts trigger post-exertional malaise. Start with walking daily. Watch for worsening symptoms — cut back immediately if they occur.
Social Support
"Simply knowing that somebody is listening to you, hearing your story and caring about you makes a huge difference." — Dr. Galland. Build and lean on your support network.
Personalized Care
Dr. Galland's foundational principle: treatment must be individualized. No two patients are the same. Work with a physician to tailor these protocols to your specific health needs.
Foundational Daily Supplement Stack
These supplements form a research-backed daily foundation for most adults, per Dr. Galland's clinical recommendations:
Foundational Wellness Supplements
Evidence-based daily supplementation for general health maintenance
| Supplement | Dosage | Why It Matters | Category |
|---|---|---|---|
Vitamin D |
2,000–4,000 IU/day |
Immune modulation; ACE2 support; bone health; mood regulation |
ACE2 |
Omega-3s (EPA + DHA) |
1,200+ mg/day |
Cardiovascular; brain health; anti-inflammatory; depression prevention |
ACE2 |
Magnesium Glycinate |
200–400 mg/day |
Nervous system; sleep; energy; palpitations; muscle function |
Foundational |
Curcumin |
500–1,000 mg/day |
Broad anti-inflammatory; cancer prevention; brain health; ACE2 support |
ACE2 |
Resveratrol |
200–500 mg/day |
Anti-aging; cardiovascular; brain health; immune support |
ACE2 |
Zinc |
15–30 mg/day |
Immune function; T-cell support; wound healing; taste/smell |
Immune |
Probiotic (Tundrex or L. plantarum)Rotate periodically |
As directed |
Microbiome maintenance; immune support; digestion; mental clarity |
Probiotic |
Ready for a Personalized Protocol?
These protocols are a starting point. Dr. Galland's approach is deeply individualized — what works for one person may need significant adjustment for another. Always work with a qualified healthcare provider to tailor any protocol to your specific situation.